› 1rjb

X-ray diffraction
2.1Å resolution

Crystal Structure of FLT3

Released:
DOI: 10.2210/pdb1rjb/pdb
PDB entry 1rjb coloured by chain, front view.
PDB entry 1rjb coloured by chain, side view.
PDB entry 1rjb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K
Mol Cell 13 169-78 (2004)
PMID: 14759363

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153242 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein kinase FLT3 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 39.8 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P36888 (Residues: 564-958; Coverage: 36%)
Gene names: CD135, FLK2, FLT3, STK1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43212
Unit cell:
a: 80.651Å b: 80.651Å c: 150.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.21 0.248
Expression system: Trichoplusia ni

Quick links

Citations

90 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
89 more

33 mentions without citation

Impact of the Protein Data Bank on antineoplastic approvals.
Westbrook et al. (2020)
32 more