› 1r14

X-ray diffraction
2.5Å resolution

Carbohydrate recognition and neck domains of surfactant protein A (Sp-A) containing samarium

Released:
DOI: 10.2210/pdb1r14/pdb
PDB entry 1r14 coloured by chain, front view.
PDB entry 1r14 coloured by chain, side view.
PDB entry 1r14 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A.
Head JF, Mealy TR, McCormack FX, Seaton BA
J Biol Chem 278 43254-60 (2003)
PMID: 12913002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140125 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein A Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.67 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia
UniProt:
  • Canonical: P08427 (Residues: 101-248; Coverage: 65%)
Gene names: Sftp-1, Sftp1, Sftpa, Sftpa1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand SM 2 x SM
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P63
Unit cell:
a: 97.68Å b: 97.68Å c: 44.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.247
Expression system: Trichoplusia

Quick links

Citations

15 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
14 more

2 mentions without citation

Lung surfactant protein A (SP-A) interactions with model lung surfactant lipids and an SP-B fragment.
Sarker et al. (2011)
1 more