› 1qvn

X-ray diffraction
2.7Å resolution

Structure of SP4160 Bound to IL-2 V69A

Released:
DOI: 10.2210/pdb1qvn/pdb
PDB entry 1qvn coloured by chain, front view.
PDB entry 1qvn coloured by chain, side view.
PDB entry 1qvn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hot-spot mimicry of a cytokine receptor by a small molecule.
Thanos CD, DeLano WL, Wells JA
Proc Natl Acad Sci U S A 103 15422-7 (2006)
PMID: 17032757

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 132 amino acids
Theoretical weight: 15.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60568 (Residues: 21-152; Coverage: 99%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand FRI 4 x FRI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 53.514Å b: 85.134Å c: 122.141Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.258 0.308
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells et al. (2007)
25 more

4 mentions without citation

Hot-spot mimicry of a cytokine receptor by a small molecule.
Thanos et al. (2006)
3 more