› 1qku

X-ray diffraction
3.2Å resolution

WILD TYPE ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL

Released:
DOI: 10.2210/pdb1qku/pdb
PDB entry 1qku coloured by chain, front view.
PDB entry 1qku coloured by chain, side view.
PDB entry 1qku coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism.
Gangloff M, Ruff M, Eiler S, Duclaud S, Wurtz JM, Moras D
J Biol Chem 276 15059-65 (2001)
PMID: 11278577

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 250 amino acids
Theoretical weight: 28.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03372 (Residues: 301-550; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand EST 3 x EST
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P3221
Unit cell:
a: 105.5Å b: 105.5Å c: 136.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.275
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
10 more

26 mentions without citation

Visualization of macromolecular structures.
O'Donoghue et al. (2010)
25 more