› 1qfv

X-ray diffraction
1.36Å resolution

HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS

Released:
DOI: 10.2210/pdb1qfv/pdb
PDB entry 1qfv coloured by chain, front view.
PDB entry 1qfv coloured by chain, side view.
PDB entry 1qfv coloured by chain, top view.
Source organism: Rhipicephalus appendiculatus
Primary publication:
Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.
Paesen GC, Adams PL, Harlos K, Nuttall PA, Stuart DI
Mol Cell 3 661-71 (1999)
PMID: 10360182

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Female-specific histamine-binding protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.81 KDa
Source organism: Rhipicephalus appendiculatus
Expression system: Spodoptera
UniProt:
  • Canonical: O77421 (Residues: 20-190; Coverage: 100%)
Sequence domains: Tick histamine binding protein
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand HSM 2 x HSM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 77.56Å b: 74.4Å c: 77.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.182 not available
Expression system: Spodoptera

Quick links

Citations

53 review citations

The lipocalin protein family: structural and sequence overview.
Flower et al. (2000)
52 more

1 mention without citation

Antihistamine response: a dynamically refined function at the host-tick interface.
Valdés JJ. (2014)