› 1qfo

X-ray diffraction
1.85Å resolution

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH 3'SIALYLLACTOSE

Released:
DOI: 10.2210/pdb1qfo/pdb
PDB entry 1qfo coloured by chain, front view.
PDB entry 1qfo coloured by chain, side view.
PDB entry 1qfo coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.
May AP, Robinson RC, Vinson M, Crocker PR, Jones EY
Mol Cell 1 719-28 (1998)
PMID: 9660955

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178923 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sialoadhesin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 119 amino acids
Theoretical weight: 13.32 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q62230 (Residues: 20-138; Coverage: 7%)
Gene names: Sa, Siglec1, Sn
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: SIA, GLC, GAL
Carbohydrate polymer
1 bound ligand:
Ligand SIA 1 x SIA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 40.93Å b: 97.59Å c: 101.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.234
Expression system: Cricetulus griseus

Quick links

Citations

29 review citations

Siglecs and their roles in the immune system.
Crocker et al. (2007)
28 more

21 mentions without citation

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer.
Daly et al. (2019)
20 more