Function and Biology Details
Reactions catalysed:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Preferential cleavage: Leu-|-, Tyr-|-, Phe-|-, Met-|-, Trp-|-, Gln-|-, Asn-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine proteases, trypsin domain
- Peptidase M14, carboxypeptidase A
- Peptidase S1A, chymotrypsin family
- Peptidase S1, PA clan, chymotrypsin-like fold
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
- Carboxypeptidase A, carboxypeptidase domain
2 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-133046 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Carboxypeptidase A1
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.8 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Carboxypeptidase activation peptide
Structure domains: Metallocarboxypeptidase-like
Length: 94 amino acids
Theoretical weight: 10.8 KDa
Source organism: Bos taurus
UniProt:
- Canonical:
P00730 (Residues: 17-110; Coverage: 23%)
Sequence domains: Carboxypeptidase activation peptide
Structure domains: Metallocarboxypeptidase-like
Carboxypeptidase A1
Molecule details ›
Chain: B
Length: 309 amino acids
Theoretical weight: 34.79 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases
Length: 309 amino acids
Theoretical weight: 34.79 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00730 (Residues: 111-419; Coverage: 77%)
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases
Proproteinase E
Molecule details ›
Chain: C
Length: 253 amino acids
Theoretical weight: 27.34 KDa
Source organism: Bos taurus
UniProt:
Structure domains: Trypsin-like serine proteases
Length: 253 amino acids
Theoretical weight: 27.34 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P05805 (Residues: 1-253; Coverage: 100%)
Structure domains: Trypsin-like serine proteases
Chymotrypsin-C
Molecule details ›
Chain: D
Length: 251 amino acids
Theoretical weight: 27.39 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 251 amino acids
Theoretical weight: 27.39 KDa
Source organism: Bos taurus
UniProt:
- Canonical: Q7M3E1 (Residues: 17-268; Coverage: 100%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
