› 1pmx

Solution NMR

INSULIN-LIKE GROWTH FACTOR-I BOUND TO A PHAGE-DERIVED PEPTIDE

Released:
DOI: 10.2210/pdb1pmx/pdb
PDB entry 1pmx coloured by chain, ensemble of 20 models, front view.
PDB entry 1pmx coloured by chain, ensemble of 20 models, side view.
PDB entry 1pmx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I.
Schaffer ML, Deshayes K, Nakamura G, Sidhu S, Skelton NJ
Biochemistry 42 9324-34 (2003)
PMID: 12899619

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138317 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like growth factor I Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05019 (Residues: 49-118; Coverage: 40%)
Gene names: IBP1, IGF1
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like
IGF-1 ANTAGONIST F1-1 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.88 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS, SIMULATED ANNEALING
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
Arkin et al. (2004)
3 more

5 mentions without citation

Structural basis of the activation of type 1 insulin-like growth factor receptor.
Li et al. (2019)
4 more