› 1pdw

X-ray diffraction
2.2Å resolution

Crystal structure of human DJ-1, P 1 21 1 space group

Released:
DOI: 10.2210/pdb1pdw/pdb
PDB entry 1pdw coloured by chain, front view.
PDB entry 1pdw coloured by chain, side view.
PDB entry 1pdw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease.
Tao X, Tong L
J Biol Chem 278 31372-9 (2003)
PMID: 12761214

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 197 amino acids
Theoretical weight: 21.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99497 (Residues: 1-189; Coverage: 100%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 32 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 71.256Å b: 83.664Å c: 114.159Å
α: 90° β: 100.56° γ: 90°
R-values:
R R work R free
0.18 0.18 0.243
Expression system: Escherichia coli

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Citations

36 review citations

Molecular pathophysiology of Parkinson's disease.
Moore et al. (2005)
35 more

2 mentions without citation

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.
Waak et al. (2009)
1 more