› 1p8t

X-ray diffraction
3.2Å resolution

Crystal structure of Nogo-66 Receptor

Released:
DOI: 10.2210/pdb1p8t/pdb
PDB entry 1p8t coloured by chain, front view.
PDB entry 1p8t coloured by chain, side view.
PDB entry 1p8t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB
EMBO J 22 3291-302 (2003)
PMID: 12839991

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189865 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Reticulon-4 receptor Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 31.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZR6 (Residues: 27-311; Coverage: 64%)
Gene names: NOGOR, RTN4R, UNQ330/PRO526
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand NDG 1 x NDG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 8-BM
Spacegroup: P3121
Unit cell:
a: 123.958Å b: 123.958Å c: 120.173Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.266 0.265 0.292

Quick links

Citations

41 review citations

Glial inhibition of CNS axon regeneration.
Yiu et al. (2006)
40 more

4 mentions without citation

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
Barton et al. (2003)
3 more