› 1ojd

X-ray diffraction
3.1Å resolution

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH Lauryldimethylamine-N-oxide (LDAO)

Released:
DOI: 10.2210/pdb1ojd/pdb
PDB entry 1ojd coloured by chain, front view.
PDB entry 1ojd coloured by chain, side view.
PDB entry 1ojd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.
Binda C, Li M, Hubalek F, Restelli N, Edmondson DE, Mattevi A
Proc Natl Acad Sci U S A 100 9750-5 (2003)
PMID: 12913124

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] B Chains: A, B, C, D, E, F, G, H, I, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, L
Length: 520 amino acids
Theoretical weight: 58.84 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P27338 (Residues: 1-520; Coverage: 100%)
Gene name: MAOB
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 10 x FAD
1 bound ligand:
Ligand LDA 10 x LDA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P1
Unit cell:
a: 108.405Å b: 132.431Å c: 154.838Å
α: 90.14° β: 90.45° γ: 114.02°
R-values:
R R work R free
0.252 0.252 0.26
Expression system: Komagataella pastoris

Quick links

Citations

35 review citations

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.
Edmondson et al. (2009)
34 more

1 mention without citation

Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.
Binda et al. (2003)