› 1oda

X-ray diffraction
3.31Å resolution

N-terminal of Sialoadhesin in complex with Me-a-9-N-(biphenyl-4-carbonyl)-amino-9-deoxy-Neu5Ac (BIP compound)

Released:
DOI: 10.2210/pdb1oda/pdb
PDB entry 1oda coloured by chain, front view.
PDB entry 1oda coloured by chain, side view.
PDB entry 1oda coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.
Zaccai NR, Maenaka K, Maenaka T, Crocker PR, Brossmer R, Kelm S, Jones EY
Structure 11 557-67 (2003)
PMID: 12737821

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178923 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialoadhesin Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.32 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q62230 (Residues: 20-138; Coverage: 7%)
Gene names: Sa, Siglec1, Sn
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand BDU 1 x BDU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P43212
Unit cell:
a: 66.61Å b: 66.61Å c: 66.947Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.284
Expression system: Cricetulus griseus

Quick links

Citations

9 review citations

Siglecs and their roles in the immune system.
Crocker et al. (2007)
8 more

2 mentions without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)
1 more