› 1o7z

X-ray diffraction
1.92Å resolution

Crystal structure of IP-10 T-form

Released:
DOI: 10.2210/pdb1o7z/pdb
PDB entry 1o7z coloured by chain, front view.
PDB entry 1o7z coloured by chain, side view.
PDB entry 1o7z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.
Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR
Structure 11 521-32 (2003)
PMID: 12737818

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 77 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02778 (Residues: 22-98; Coverage: 100%)
Gene names: CXCL10, INP10, SCYB10
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P41212
Unit cell:
a: 59.437Å b: 59.437Å c: 121.708Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.279 0.298
Expression system: Not provided

Quick links

Citations

15 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
14 more

5 mentions without citation

HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads.
Borgmann et al. (2015)
4 more