› 1neu

X-ray diffraction
1.9Å resolution

STRUCTURE OF MYELIN MEMBRANE ADHESION MOLECULE P0

Released:
DOI: 10.2210/pdb1neu/pdb
PDB entry 1neu coloured by chain, front view.
PDB entry 1neu coloured by chain, side view.
PDB entry 1neu coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin.
Shapiro L, Doyle JP, Hensley P, Colman DR, Hendrickson WA
Neuron 17 435-49 (1996)
PMID: 8816707

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin protein P0 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P06907 (Residues: 30-153; Coverage: 57%)
Gene names: Mpz, P0
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I422
Unit cell:
a: 88.9Å b: 88.9Å c: 91.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.268
Expression system: Escherichia coli

Quick links

Citations

75 review citations

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
Catterall WA. (2000)
74 more

24 mentions without citation

Overview of myelin, major myelin lipids, and myelin-associated proteins.
Kister et al. (2022)
23 more