› 1mvj

Solution NMR

N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES

Released:
DOI: 10.2210/pdb1mvj/pdb
PDB entry 1mvj coloured by chain, ensemble of 15 models, front view.
PDB entry 1mvj coloured by chain, ensemble of 15 models, side view.
PDB entry 1mvj coloured by chain, ensemble of 15 models, top view.
Source organism: Conus striatus
Primary publication:
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.
Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ
J Mol Biol 263 297-310 (1996)
PMID: 8913308

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Omega-conotoxin SVIB Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.75 KDa
Source organism: Conus striatus
Expression system: Not provided
UniProt:
  • Canonical: P28881 (Residues: 46-71; Coverage: 52%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MD/SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

14 review citations

The cystine knot motif in toxins and implications for drug design.
Craik et al. (2001)
13 more

3 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
2 more