› 1lm5

X-ray diffraction
1.8Å resolution

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

Released:
DOI: 10.2210/pdb1lm5/pdb
PDB entry 1lm5 coloured by chain, front view.
PDB entry 1lm5 coloured by chain, side view.
PDB entry 1lm5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.
Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI
Nat Struct Biol 9 612-20 (2002)
PMID: 12101406

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Desmoplakin Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15924 (Residues: 2609-2822; Coverage: 8%)
Gene name: DSP
Sequence domains: Plectin repeat
Structure domains: Plakin repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 68.32Å b: 95.379Å c: 54.982Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.247
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds.
Herrmann et al. (2004)
28 more

7 mentions without citation

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
6 more