› 1lfb

X-ray diffraction
2.8Å resolution

THE X-RAY STRUCTURE OF AN ATYPICAL HOMEODOMAIN PRESENT IN THE RAT LIVER TRANSCRIPTION FACTOR LFB1(SLASH)HNF1 AND IMPLICATIONS FOR DNA BINDING

Released:
DOI: 10.2210/pdb1lfb/pdb
PDB entry 1lfb coloured by chain, front view.
PDB entry 1lfb coloured by chain, side view.
PDB entry 1lfb coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding.
Ceska TA, Lamers M, Monaci P, Nicosia A, Cortese R, Suck D
EMBO J 12 1805-10 (1993)
PMID: 8491173

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 1-alpha Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.68 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P15257 (Residues: 195-286; Coverage: 15%)
Gene names: Hnf-1, Hnf-1a, Hnf1a, Tcf1
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6122
Unit cell:
a: 81.03Å b: 81.03Å c: 85.18Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.212 0.364
Expression system: Not provided

Quick links

Citations

6 review citations

Homeodomain-DNA recognition.
Gehring et al. (1994)
5 more

16 mentions without citation

An accurate, residue-level, pair potential of mean force for folding and binding based on the distance-scaled, ideal-gas reference state.
Zhang et al. (2004)
15 more