› 1kui

X-ray diffraction
1.5Å resolution

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with pEQW.

Released:
DOI: 10.2210/pdb1kui/pdb
PDB entry 1kui coloured by chain, front view.
PDB entry 1kui coloured by chain, side view.
PDB entry 1kui coloured by chain, top view.
Source organism: Protobothrops mucrosquamatus
Primary publication:
Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.
Huang KF, Chiou SH, Ko TP, Wang AH
Eur J Biochem 269 3047-56 (2002)
PMID: 12071970

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129591 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Snake venom metalloproteinase TM-3 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 23.38 KDa
Source organism: Protobothrops mucrosquamatus
UniProt:
  • Canonical: O57413 (Residues: 190-392; Coverage: 44%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)
EQW Chain: B
Molecule details ›
Chain: B
Length: 3 amino acids
Theoretical weight: 443 Da
Source organism: Protobothrops mucrosquamatus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CD 10 x CD
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P41212
Unit cell:
a: 61.082Å b: 61.082Å c: 127.593Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 0.216
Expression system: Not provided

Quick links

Citations

3 review citations

Inhibitors of snake venoms and development of new therapeutics.
Sánchez et al. (2008)
2 more

1 mention without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)