› 1kuf

X-ray diffraction
1.35Å resolution

High-resolution Crystal Structure of a Snake Venom Metalloproteinase from Taiwan Habu

Released:
DOI: 10.2210/pdb1kuf/pdb
PDB entry 1kuf coloured by chain, front view.
PDB entry 1kuf coloured by chain, side view.
PDB entry 1kuf coloured by chain, top view.
Source organism: Protobothrops mucrosquamatus
Primary publication:
The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium.
Huang KF, Chiou SH, Ko TP, Yuann JM, Wang AH
Acta Crystallogr D Biol Crystallogr 58 1118-28 (2002)
PMID: 12077431

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase TM-3 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 23.38 KDa
Source organism: Protobothrops mucrosquamatus
UniProt:
  • Canonical: O57413 (Residues: 190-392; Coverage: 44%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

1 bound ligand:
Ligand CD 10 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P41212
Unit cell:
a: 60.991Å b: 60.991Å c: 128.398Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.181 0.204

Quick links

Citations

5 review citations

Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases.
Fox et al. (2005)
4 more

6 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
5 more