› 1krm

X-ray diffraction
2.5Å resolution

Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside

Released:
DOI: 10.2210/pdb1krm/pdb
PDB entry 1krm coloured by chain, front view.
PDB entry 1krm coloured by chain, side view.
PDB entry 1krm coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.
Kinoshita T, Nishio N, Nakanishi I, Sato A, Fujii T
Acta Crystallogr D Biol Crystallogr 59 299-303 (2003)
PMID: 12554940

Function and Biology Details

Reaction catalysed: 
2'-deoxyadenosine + H(2)O = 2'-deoxyinosine + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine deaminase Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.33 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P56658 (Residues: 2-357; Coverage: 98%)
Gene name: ADA
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand PRH 1 x PRH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P43212
Unit cell:
a: 80.03Å b: 80.03Å c: 141.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.198

Quick links

Citations

7 citation in other articles

Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.
Losey et al. (2006)
6 more

14 mentions without citation

Sampling protein motion and solvent effect during ligand binding.
Limongelli et al. (2012)
13 more