› 1kpc

X-ray diffraction
2.2Å resolution

PKCI-1-APO+ZINC

Released:
DOI: 10.2210/pdb1kpc/pdb
PDB entry 1kpc coloured by chain, front view.
PDB entry 1kpc coloured by chain, side view.
PDB entry 1kpc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.
Lima CD, Klein MG, Weinstein IB, Hendrickson WA
Proc Natl Acad Sci U S A 93 5357-62 (1996)
PMID: 8643579

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 126 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P49773 (Residues: 2-126; Coverage: 99%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Sequence domains: HIT domain
Structure domains: HIT-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 63.94Å b: 78.66Å c: 46.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.309
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Heterologous protein expression in the methylotrophic yeast Pichia pastoris.
Cereghino et al. (2000)
12 more

2 mentions without citation

A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 Å resolution.
Dolot et al. (2012)
1 more