› 1k05

X-ray diffraction
2.9Å resolution

Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase

Released:
DOI: 10.2210/pdb1k05/pdb
PDB entry 1k05 coloured by chain, front view.
PDB entry 1k05 coloured by chain, side view.
PDB entry 1k05 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of localization and signaling by the focal adhesion targeting domain.
Arold ST, Hoellerer MK, Noble ME
Structure 10 319-27 (2002)
PMID: 12005431

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05397 (Residues: 891-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: C2221
Unit cell:
a: 87.484Å b: 222.101Å c: 97.885Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.285
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Paxillin: adapting to change.
Brown et al. (2004)
21 more

9 mentions without citation

Psychological therapies for temporomandibular disorders (TMDs).
Penlington et al. (2022)
8 more