› 1jln

X-ray diffraction
1.81Å resolution

Crystal structure of the catalytic domain of protein tyrosine phosphatase PTP-SL/BR7

Released:
DOI: 10.2210/pdb1jln/pdb
PDB entry 1jln coloured by chain, front view.
PDB entry 1jln coloured by chain, side view.
PDB entry 1jln coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
Szedlacsek SE, Aricescu AR, Fulga TA, Renault L, Scheidig AJ
J Mol Biol 311 557-68 (2001)
PMID: 11493009

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178914 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase R Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62132 (Residues: 360-655; Coverage: 47%)
Gene names: Ptp13, Ptprr
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P212121
Unit cell:
a: 46.136Å b: 65.322Å c: 105.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.245
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein tyrosine phosphatases: structure-function relationships.
Tabernero et al. (2008)
1 more

3 mentions without citation

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Eswaran et al. (2006)
2 more