› 1j78

X-ray diffraction
2.31Å resolution

Crystallographic analysis of the human vitamin D binding protein

Released:
DOI: 10.2210/pdb1j78/pdb
PDB entry 1j78 coloured by chain, front view.
PDB entry 1j78 coloured by chain, side view.
PDB entry 1j78 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A structural basis for the unique binding features of the human vitamin D-binding protein.
Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C
Nat Struct Biol 9 131-6 (2002)
PMID: 11799400

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136195 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin D-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 458 amino acids
Theoretical weight: 51.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02774 (Residues: 17-474; Coverage: 100%)
Gene name: GC
Sequence domains:
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand OLA 3 x OLA
Ligand VDY 1 x VDY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P43
Unit cell:
a: 132.248Å b: 132.248Å c: 73.179Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.252

Quick links

Citations

15 review citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model.
Norman et al. (2004)
14 more

10 mentions without citation

Conformational changes in redox pairs of protein structures.
Fan et al. (2009)
9 more