› 1j6w

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reaction catalysed: 
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
S-ribosylhomocysteine lyase Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.85 KDa
Source organism: Haemophilus influenzae
Expression system: Escherichia coli
UniProt:
  • Canonical: P44007 (Residues: 2-167; Coverage: 99%)
Gene names: HI_0491, luxS
Sequence domains: S-Ribosylhomocysteinase (LuxS)
Structure domains: S-ribosylhomocysteinase (LuxS)

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand MET 2 x MET
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P42212
Unit cell:
a: 129.669Å b: 129.669Å c: 53.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.238
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria.
Vendeville et al. (2005)
12 more

4 mentions without citation

Functional correlation of bacterial LuxS with their quaternary associations: interface analysis of the structure networks.
Bhattacharyya et al. (2009)
3 more