› 1j6u

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194476 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-N-acetylmuramate--L-alanine ligase Chain: A
Molecule details ›
Chain: A
Length: 469 amino acids
Theoretical weight: 53.83 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WY73 (Residues: 1-457; Coverage: 100%)
Gene names: TM_0231, murC
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: I4132
Unit cell:
a: 244.11Å b: 244.11Å c: 244.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.234 0.279
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Cytoplasmic steps of peptidoglycan biosynthesis.
Barreteau et al. (2008)
4 more

6 mentions without citation

Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis.
Laddomada et al. (2016)
5 more