› 1iwo

X-ray diffraction
3.1Å resolution

Crystal structure of the SR Ca2+-ATPase in the absence of Ca2+

Released:
DOI: 10.2210/pdb1iwo/pdb
PDB entry 1iwo coloured by chain, front view.
PDB entry 1iwo coloured by chain, side view.
PDB entry 1iwo coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural changes in the calcium pump accompanying the dissociation of calcium.
Toyoshima C, Nomura H
Nature 418 605-11 (2002)
PMID: 12167852

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 994 amino acids
Theoretical weight: 109.6 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand TG1 2 x TG1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P41
Unit cell:
a: 71.739Å b: 71.739Å c: 590.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.237 0.268

Quick links

Citations

98 review citations

Phospholamban: a crucial regulator of cardiac contractility.
MacLennan et al. (2003)
97 more

65 mentions without citation

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.
Lundbaek et al. (2010)
64 more