› 1ie9

X-ray diffraction
1.4Å resolution

Crystal Structure Of The Nuclear Receptor For Vitamin D Ligand Binding Domain Bound to MC1288

Released:
DOI: 10.2210/pdb1ie9/pdb
PDB entry 1ie9 coloured by chain, front view.
PDB entry 1ie9 coloured by chain, side view.
PDB entry 1ie9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.
Tocchini-Valentini G, Rochel N, Wurtz JM, Mitschler A, Moras D
Proc Natl Acad Sci U S A 98 5491-6 (2001)
PMID: 11344298

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin D3 receptor Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11473 (Residues: 118-427; Coverage: 61%)
Gene names: NR1I1, VDR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand VDX 1 x VDX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P212121
Unit cell:
a: 44.94Å b: 51.42Å c: 132.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.248
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
Christakos et al. (2016)
26 more

13 mentions without citation

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.
Tocchini-Valentini et al. (2001)
12 more