› 1h9u

X-ray diffraction
2.7Å resolution

The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268

Released:
DOI: 10.2210/pdb1h9u/pdb
PDB entry 1h9u coloured by chain, front view.
PDB entry 1h9u coloured by chain, side view.
PDB entry 1h9u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
Love JD, Gooch JT, Benko S, Li C, Nagy L, Chatterjee VK, Evans RM, Schwabe JW
J Biol Chem 277 11385-91 (2002)
PMID: 11782480

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 224 amino acids
Theoretical weight: 24.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28702 (Residues: 299-522; Coverage: 42%)
Gene names: NR2B2, RXRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand LG2 4 x LG2
Ligand NI 4 x NI
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 123.886Å b: 106.882Å c: 100.587Å
α: 90° β: 122.56° γ: 90°
R-values:
R R work R free
0.273 0.273 0.306
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Deciphering the nuclear bile acid receptor FXR paradigm.
Modica et al. (2010)
3 more

15 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
14 more