› 1h6p

X-ray diffraction
2.2Å resolution

Dimeristion domain from human TRF2

Released:
DOI: 10.2210/pdb1h6p/pdb
PDB entry 1h6p coloured by chain, front view.
PDB entry 1h6p coloured by chain, side view.
PDB entry 1h6p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
Fairall L, Chapman L, Moss H, de Lange T, Rhodes D
Mol Cell 8 351-61 (2001)
PMID: 11545737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomeric repeat-binding factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15554 (Residues: 85-287; Coverage: 38%)
Gene names: TERF2, TRBF2, TRF2
Sequence domains: Telomere repeat binding factor (TRF)
Structure domains: Telomere repeat-binding factor, dimerisation domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: C2
Unit cell:
a: 117.041Å b: 80.284Å c: 52.816Å
α: 90° β: 101.95° γ: 90°
R-values:
R R work R free
0.235 0.235 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

30 review citations

How shelterin protects mammalian telomeres.
Palm et al. (2008)
29 more

13 mentions without citation

Finding the end: recruitment of telomerase to telomeres.
Nandakumar et al. (2013)
12 more