› 1gup

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactose-1-phosphate uridylyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 348 amino acids
Theoretical weight: 39.61 KDa
Source organism: Escherichia coli
Expression system: Not provided
UniProt:
  • Canonical: P09148 (Residues: 1-348; Coverage: 100%)
Gene names: JW0741, b0758, galB, galT
Sequence domains:
Structure domains: HIT-like

Ligands and Environments

4 bound ligands:
Ligand GDU 4 x GDU
Ligand ZN 4 x ZN
Ligand FE 4 x FE
Ligand K 4 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 68.7Å b: 57.7Å c: 188.7Å
α: 90° β: 100.08° γ: 90°
R-values:
R R work R free
0.191 0.191 not available
Expression system: Not provided

Quick links

Citations

6 review citations

Structure and function of enzymes of the Leloir pathway for galactose metabolism.
Holden et al. (2003)
5 more

4 mentions without citation

HotPatch: a statistical approach to finding biologically relevant features on protein surfaces.
Pettit et al. (2007)
3 more