› 1gta

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURES OF A SCHISTOSOMAL DRUG AND VACCINE TARGET: GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA AND ITS COMPLEX WITH THE LEADING ANTISCHISTOSOMAL DRUG PRAZIQUANTEL

Released:
DOI: 10.2210/pdb1gta/pdb
PDB entry 1gta coloured by chain, front view.
PDB entry 1gta coloured by chain, side view.
PDB entry 1gta coloured by chain, top view.
Source organism: Schistosoma japonicum
Primary publication:
Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
McTigue MA, Williams DR, Tainer JA
J Mol Biol 246 21-7 (1995)
PMID: 7853399

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase class-mu 26 kDa isozyme Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 25.53 KDa
Source organism: Schistosoma japonicum
Expression system: Not provided
UniProt:
  • Canonical: P08515 (Residues: 1-218; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6322
Unit cell:
a: 125.2Å b: 125.2Å c: 70.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.197 not available
Expression system: Not provided

Quick links

Citations

19 review citations

Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Sheehan et al. (2001)
18 more

10 mentions without citation

Probing structures of large protein complexes using zero-length cross-linking.
Rivera-Santiago et al. (2015)
9 more