› 1gqm

X-ray diffraction
2.7Å resolution

The structure of S100A12 in a hexameric form and its proposed role in receptor signalling

Released:
DOI: 10.2210/pdb1gqm/pdb
PDB entry 1gqm coloured by chain, front view.
PDB entry 1gqm coloured by chain, side view.
PDB entry 1gqm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of S100A12 in a hexameric form and its proposed role in receptor signalling.
Moroz OV, Antson AA, Dodson EJ, Burrell HJ, Grist SJ, Lloyd RM, Maitland NJ, Dodson GG, Wilson KS, Lukanidin E, Bronstein IB
Acta Crystallogr D Biol Crystallogr 58 407-13 (2002)
PMID: 11856825

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160421 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A12 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 91 amino acids
Theoretical weight: 10.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 36 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 53.875Å b: 100.501Å c: 112.687Å
α: 90° β: 94.55° γ: 90°
R-values:
R R work R free
0.219 0.217 0.281

Quick links

Citations

20 review citations

S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature).
Marenholz et al. (2004)
19 more

6 mentions without citation

Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family.
Wheeler et al. (2016)
5 more