› 1fvq

Solution NMR

SOLUTION STRUCTURE OF THE YEAST COPPER TRANSPORTER DOMAIN CCC2A IN THE APO AND CU(I) LOADED STATES

Released:
DOI: 10.2210/pdb1fvq/pdb
PDB entry 1fvq coloured by chain, front view.
PDB entry 1fvq coloured by chain, side view.
PDB entry 1fvq coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Solution structure of the yeast copper transporter domain Ccc2a in the apo and Cu(I)-loaded states.
Banci L, Bertini I, Ciofi-Baffoni S, Huffman DL, O'Halloran TV
J Biol Chem 276 8415-26 (2001)
PMID: 11083871

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 7.89 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P38995 (Residues: 2-72; Coverage: 7%)
Gene names: CCC2, D9954.6, YDR270W
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics restrained energy minimization
Expression system: Escherichia coli

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Citations

13 review citations

Molecular mechanisms of copper uptake and distribution.
Puig et al. (2002)
12 more

8 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
7 more