› 1fdh

X-ray diffraction
2.5Å resolution

STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN

Released:
DOI: 10.2210/pdb1fdh/pdb
PDB entry 1fdh coloured by chain, front view.
PDB entry 1fdh coloured by chain, side view.
PDB entry 1fdh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human foetal deoxyhaemoglobin.
Frier JA, Perutz MF
J Mol Biol 112 97-112 (1977)
PMID: 881729

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159679 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit gamma-2 Chains: G, H
Molecule details ›
Chains: G, H
Length: 147 amino acids
Theoretical weight: 16.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P69892 (Residues: 2-147; Coverage: 99%)
Gene name: HBG2
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEM 4 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 62.8Å b: 95.1Å c: 102.1Å
α: 90° β: 90° γ: 90°
Expression system: Not provided

Quick links

Citations

7 review citations

Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (first of three parts).
Dean et al. (1978)
6 more

9 mentions without citation

Characterizing metal-binding sites in proteins with X-ray crystallography.
Handing et al. (2018)
8 more