› 1ewt

X-ray diffraction
3.7Å resolution

CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 LIGAND FREE FORM I

Released:
DOI: 10.2210/pdb1ewt/pdb
PDB entry 1ewt coloured by chain, front view.
PDB entry 1ewt coloured by chain, side view.
PDB entry 1ewt coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K
Nature 407 971-7 (2000)
PMID: 11069170

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 490 amino acids
Theoretical weight: 55.26 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23385 (Residues: 33-522; Coverage: 42%)
Gene names: Gprc1a, Grm1, Mglur1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P41212
Unit cell:
a: 111.436Å b: 111.436Å c: 293.673Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.287
Expression system: Spodoptera frugiperda

Quick links

Citations

210 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
209 more

42 mentions without citation

Metabotropic glutamate receptors: from the workbench to the bedside.
Nicoletti et al. (2011)
41 more