› 1eq8

Solid-state NMR

THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT

Released:
DOI: 10.2210/pdb1eq8/pdb
PDB entry 1eq8 coloured by chain, front view.
PDB entry 1eq8 coloured by chain, side view.
PDB entry 1eq8 coloured by chain, top view.
Source organism: Tetronarce californica
Primary publication:
Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy.
Opella SJ, Marassi FM, Gesell JJ, Valente AP, Kim Y, Oblatt-Montal M, Montal M
Nat Struct Biol 6 374-9 (1999)
PMID: 10201407

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136097 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholine receptor subunit delta Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 23 amino acids
Theoretical weight: 2.52 KDa
Source organism: Tetronarce californica
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02718 (Residues: 276-298; Coverage: 5%)
Gene name: chrnd

Ligands and Environments

1 bound ligand:
Ligand OH 1 x OH
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: X-PLOR 3.1, distance geometry, simulated annealing, molecular dynamics, FISI, FINGERPRINT, HOLE
Expression system: Escherichia coli BL21

Quick links

Citations

46 review citations

Nicotinic receptors at the amino acid level.
Corringer et al. (2000)
45 more

15 mentions without citation

A de novo peptide hexamer with a mutable channel.
Zaccai et al. (2011)
14 more