› 1eaj

X-ray diffraction
1.35Å resolution

DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN AT 1.35 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1eaj/pdb
PDB entry 1eaj coloured by chain, front view.
PDB entry 1eaj coloured by chain, side view.
PDB entry 1eaj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.
van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S
Structure 8 1147-55 (2000)
PMID: 11080637

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coxsackievirus and adenovirus receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78310 (Residues: 15-140; Coverage: 35%)
Gene names: CAR, CXADR
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P43212
Unit cell:
a: 68.538Å b: 68.538Å c: 146.406Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.137 0.137 0.148
Expression system: Escherichia coli

Quick links

Citations

29 review citations

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Freeman et al. (2010)
28 more

13 mentions without citation

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Wang et al. (2011)
12 more