› 1e4j

X-ray diffraction
2.5Å resolution

Crystal structure of the soluble human Fc-gamma Receptor III

Released:
DOI: 10.2210/pdb1e4j/pdb
PDB entry 1e4j coloured by chain, front view.
PDB entry 1e4j coloured by chain, side view.
PDB entry 1e4j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.
Sondermann P, Huber R, Oosthuizen V, Jacob U
Nature 406 267-73 (2000)
PMID: 10917521

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin gamma Fc region receptor III-B Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 20.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75015 (Residues: 18-193; Coverage: 81%)
Gene names: CD16B, FCG3, FCGR3, FCGR3B, IGFR3
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Unit cell:
a: 36.7Å b: 60.29Å c: 85.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.261
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

128 review citations

Fcgamma receptors as regulators of immune responses.
Nimmerjahn et al. (2008)
127 more

12 mentions without citation

Fc gamma receptors: glycobiology and therapeutic prospects.
Hayes et al. (2016)
11 more