› 1e3f

X-ray diffraction
1.9Å resolution

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Released:
DOI: 10.2210/pdb1e3f/pdb
PDB entry 1e3f coloured by chain, front view.
PDB entry 1e3f coloured by chain, side view.
PDB entry 1e3f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human transthyretin complexed with bromophenols: a new mode of binding.
Ghosh M, Meerts IA, Cook A, Bergman A, Brouwer A, Johnson LN
Acta Crystallogr D Biol Crystallogr 56 1085-95 (2000)
PMID: 10957627

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21212
Unit cell:
a: 42.7Å b: 85.4Å c: 64.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.252

Quick links

Citations

6 review citations

Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.
Hou et al. (2007)
5 more

2 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
1 more