› 1dxy

X-ray diffraction
1.86Å resolution

STRUCTURE OF D-2-HYDROXYISOCAPROATE DEHYDROGENASE

Released:
DOI: 10.2210/pdb1dxy/pdb
PDB entry 1dxy coloured by chain, front view.
PDB entry 1dxy coloured by chain, side view.
PDB entry 1dxy coloured by chain, top view.
Source organism: Lacticaseibacillus casei
Primary publication:
Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution.
Dengler U, Niefind K, Kiess M, Schomburg D
J Mol Biol 267 640-60 (1997)
PMID: 9126843

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-148102 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-2-hydroxyisocaproate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 36.93 KDa
Source organism: Lacticaseibacillus casei
Expression system: Escherichia coli
UniProt:
  • Canonical: P17584 (Residues: 1-333; Coverage: 100%)
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand NAD 1 x NAD
Ligand COI 1 x COI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P6322
Unit cell:
a: 134.1Å b: 134.1Å c: 125.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.217
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Molecular mechanisms of vancomycin resistance.
Stogios et al. (2020)
2 more

7 mentions without citation

CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission.
Nardini et al. (2003)
6 more