› 1dr7

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES

Released:
DOI: 10.2210/pdb1dr7/pdb
PDB entry 1dr7 coloured by chain, front view.
PDB entry 1dr7 coloured by chain, side view.
PDB entry 1dr7 coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Mctigue MA, Davies /II JF, Kaufman BT, Xuong N-H, Kraut J

Function and Biology Details

Reaction catalysed: 
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132451 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrofolate reductase Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.68 KDa
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P00378 (Residues: 1-189; Coverage: 100%)
Gene name: DHFR
Sequence domains: Dihydrofolate reductase
Structure domains: Dihydrofolate Reductase, subunit A

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
2 bound ligands:
Ligand CA 1 x CA
Ligand MBO 1 x MBO
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 88.72Å b: 48.74Å c: 63.87Å
α: 90° β: 124.4° γ: 90°
R-values:
R R work R free
0.158 not available not available
Expression system: Not provided

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