› 1dk8

X-ray diffraction
1.57Å resolution

CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN

Released:
DOI: 10.2210/pdb1dk8/pdb
PDB entry 1dk8 coloured by chain, front view.
PDB entry 1dk8 coloured by chain, side view.
PDB entry 1dk8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the Axin-adenomatous polyposis coli interaction.
Spink KE, Polakis P, Weis WI
EMBO J 19 2270-9 (2000)
PMID: 10811618

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Axin-1 Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 16.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15169 (Residues: 74-220; Coverage: 17%)
Gene names: AXIN, AXIN1
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 6 x SO4
Ligand DTT 1 x DTT
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2221
Unit cell:
a: 32.57Å b: 117.88Å c: 81.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.198
Expression system: Escherichia coli

Quick links

Citations

43 review citations

Wnt/beta-catenin signaling in development and disease.
Clevers H. (2006)
42 more

11 mentions without citation

Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology.
Papanagnou et al. (2019)
10 more