› 1cwo

X-ray diffraction
1.86Å resolution

HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN

Released:
DOI: 10.2210/pdb1cwo/pdb
PDB entry 1cwo coloured by chain, front view.
PDB entry 1cwo coloured by chain, side view.
PDB entry 1cwo coloured by chain, top view.
Source organisms:
Primary publication:
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A.
Mikol V, Taylor P, Kallen J, Walkinshaw MD
J Mol Biol 283 451-61 (1998)
PMID: 9769217

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158785 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN C Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.27 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
5 modified residues:
Ligand VAD 1 x VAD
Ligand MLE 3 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P212121
Unit cell:
a: 36.41Å b: 57.44Å c: 71.9Å
α: 90° β: 90° γ: 90°
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Immunophilins: switched on protein binding domains?
Ivery MT. (2000)
1 other article