› 1clp

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF A CALCIUM-INDEPENDENT PHOSPHOLIPASELIKE MYOTOXIC PROTEIN FROM BOTHROPS ASPER VENOM

Released:
DOI: 10.2210/pdb1clp/pdb
PDB entry 1clp coloured by chain, front view.
PDB entry 1clp coloured by chain, side view.
PDB entry 1clp coloured by chain, top view.
Source organism: Bothrops asper
Primary publication:
Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom.
Arni RK, Ward RJ, Gutierrez JM, Tulinsky A
Acta Crystallogr D Biol Crystallogr 51 311-7 (1995)
PMID: 15299297

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.76 KDa
Source organism: Bothrops asper
Expression system: Not provided
UniProt:
  • Canonical: P24605 (Residues: 17-137; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 50.18Å b: 67.76Å c: 88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.165 not available
Expression system: Not provided

Quick links

Citations

4 review citations

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.
Lomonte et al. (2003)
3 more

9 mentions without citation

Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Zhou et al. (2008)
8 more