› 1cks

X-ray diffraction
2.1Å resolution

HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

Released:
DOI: 10.2210/pdb1cks/pdb
PDB entry 1cks coloured by chain, front view.
PDB entry 1cks coloured by chain, side view.
PDB entry 1cks coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA
Science 262 387-95 (1993)
PMID: 8211159

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152621 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinases regulatory subunit 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 79 amino acids
Theoretical weight: 9.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P33552 (Residues: 1-79; Coverage: 100%)
Gene name: CKS2
Sequence domains: Cyclin-dependent kinase regulatory subunit
Structure domains: Cyclin-dependent kinase, regulatory subunit

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 100.1Å b: 57.6Å c: 51.1Å
α: 90° β: 117.4° γ: 90°
R-values:
R R work R free
0.168 0.168 not available
Expression system: Not provided

Quick links

Citations

23 review citations

Principles of CDK regulation.
Morgan DO. (1995)
22 more

5 mentions without citation

What lessons can be learned from studying the folding of homologous proteins?
Nickson et al. (2010)
4 more