› 1bfe

X-ray diffraction
2.3Å resolution

THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95

Released:
DOI: 10.2210/pdb1bfe/pdb
PDB entry 1bfe coloured by chain, front view.
PDB entry 1bfe coloured by chain, side view.
PDB entry 1bfe coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R
Cell 85 1067-76 (1996)
PMID: 8674113

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.75 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31016 (Residues: 298-402; Coverage: 15%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P4132
Unit cell:
a: 89.2Å b: 89.2Å c: 89.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.315
Expression system: Escherichia coli BL21

Quick links

Citations

132 review citations

Mechanisms of Wnt signaling in development.
Wodarz et al. (1998)
131 more

31 mentions without citation

Change in allosteric network affects binding affinities of PDZ domains: analysis through perturbation response scanning.
Gerek et al. (2011)
30 more