› 1aoj

X-ray diffraction
2.5Å resolution

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

Released:
DOI: 10.2210/pdb1aoj/pdb
PDB entry 1aoj coloured by chain, front view.
PDB entry 1aoj coloured by chain, side view.
PDB entry 1aoj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The SH3 domain of Eps8 exists as a novel intertwined dimer.
Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME
Nat Struct Biol 4 739-43 (1997)
PMID: 9303002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor kinase substrate 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 7.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08509 (Residues: 532-591; Coverage: 7%)
Gene name: Eps8
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P1
Unit cell:
a: 27.69Å b: 28.338Å c: 36.825Å
α: 107.53° β: 96.83° γ: 104.51°
R-values:
R R work R free
0.193 0.193 0.27
Expression system: Escherichia coli

Quick links

Citations

16 review citations

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains.
Kay et al. (2000)
15 more

6 mentions without citation

The Landscape of Intertwined Associations in Homooligomeric Proteins.
Wodak et al. (2015)
5 more