› 1ad4

X-ray diffraction
2.4Å resolution

DIHYDROPTEROATE SYNTHETASE COMPLEXED WITH OH-CH2-PTERIN-PYROPHOSPHATE FROM STAPHYLOCOCCUS AUREUS

Released:
DOI: 10.2210/pdb1ad4/pdb
PDB entry 1ad4 coloured by chain, front view.
PDB entry 1ad4 coloured by chain, side view.
PDB entry 1ad4 coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
Hampele IC, D'Arcy A, Dale GE, Kostrewa D, Nielsen J, Oefner C, Page MG, Schönfeld HJ, Stüber D, Then RL
J Mol Biol 268 21-30 (1997)
PMID: 9149138

Function and Biology Details

Reaction catalysed: 
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropteroate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 29.4 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: O05701 (Residues: 2-267; Coverage: 100%)
Gene names: dpsA, folP
Sequence domains: Pterin binding enzyme
Structure domains: Dihydropteroate synthase-like

Ligands and Environments

3 bound ligands:
Ligand MN 3 x MN
Ligand K 2 x K
Ligand HH2 1 x HH2
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 65.748Å b: 42.142Å c: 99.04Å
α: 90° β: 106.06° γ: 90°
R-values:
R R work R free
0.176 0.176 not available

Quick links

Citations

19 review citations

Antibiotic resistance in Staphylococcus aureus. Current status and future prospects.
Foster TJ. (2017)
18 more

8 mentions without citation

Ca2+ current and charge movements in skeletal myotubes promoted by the beta-subunit of the dihydropyridine receptor in the absence of ryanodine receptor type 1.
Ahern et al. (2003)
7 more