16gs Summary

pdbe.org/16gs
spacer

GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3

The structure was published by Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., and Parker, M.W., in 1998 in a paper entitled "Evidence for an induced-fit mechanism operating in pi class glutathione transferases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE S-TRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 99%
B GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09211 (1 - 210) GLUTATHIONE S-TRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09211) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P09211) glutathione transferase activitysearch dinitrosyl-iron complex bindingsearch JUN kinase bindingsearch S-nitrosoglutathione bindingsearch protein bindingsearch transferase activitysearch kinase regulator activitysearch nitric oxide bindingsearch negative regulation of MAPK cascadesearch negative regulation of protein kinase activitysearch response to reactive oxygen speciessearch glutathione metabolic processsearch negative regulation of tumor necrosis factor productionsearch negative regulation of I-kappaB kinase/NF-kappaB signalingsearch xenobiotic metabolic processsearch metabolic processsearch nitric oxide storagesearch small molecule metabolic processsearch negative regulation of stress-activated MAPK cascadesearch positive regulation of superoxide anion generationsearch negative regulation of MAP kinase activitysearch negative regulation of extrinsic apoptotic signaling pathwaysearch cellular response to lipopolysaccharidesearch negative regulation of fibroblast proliferationsearch negative regulation of JUN kinase activitysearch negative regulation of tumor necrosis factor-mediated signaling pathwaysearch negative regulation of nitric-oxide synthase biosynthetic processsearch negative regulation of interleukin-1 beta productionsearch negative regulation of biosynthetic processsearch negative regulation of apoptotic processsearch negative regulation of monocyte chemotactic protein-1 productionsearch negative regulation of acute inflammatory responsesearch regulation of ERK1 and ERK2 cascadesearch regulation of stress-activated MAPK cascadesearch negative regulation of ERK1 and ERK2 cascadesearch common myeloid progenitor cell proliferationsearch central nervous system developmentsearch negative regulation of leukocyte proliferationsearch glutathione derivative biosynthetic processsearch TRAF2-GSTP1 complexsearch extracellular vesicular exosomesearch mitochondrionsearch cytoplasmsearch vesiclesearch extracellular spacesearch cytosolsearch nucleussearch intracellularsearch plasma membranesearch

Chain InterPro annotation
A, B Glutathione S-transferase, Pi classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch